Darlène joined the Legal Network's board of directors in 2004 and served as Vice President in 2006–2007.
She is a Coordinator of the front-line intervention team at CACTUS Montréal, a community-based harm-reduction group that runs a centre for distribution of prevention material for people who use drugs and provides support for people who do sex work.
A long-time sex worker and recovering drug addict, Darlène shares her experience and expertise at harm reduction and AIDS research conferences in Canada and around the world. She is a member of a Health Canada committee on safe injection sites and co-authored a feasibility report on supervised injection facilities in Montréal. She has worked with the North American Opiate Medication Initiative (NAOMI), and, since 1996, coordinates the Réseau I-Track/SurvUDI Montréal, a Quebec epidemiology study on HIV/AIDS and Hepatitis C among people who inject drugs. From 1995 to 1998, she worked at, and served on the Board of directors of Stella, a drop-in resource centre in Montréal run by and for sex workers.
In 2003, Châtelaine magazine voted Darlène a woman of the year for her resilience and dedication to improving the quality of life for people who inject drugs. In April 2003, the Farha Foundation saluted Darlène as one of Quebec's heroes who, by their concrete and necessary actions, are giving of their heart and soul in a tireless fight against this disease and the prejudices associated with it.